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KMID : 0383819820290040183
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Tuberculosis and Respiratory Diseases
1982 Volume.29 No. 4 p.183 ~ p.188
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Follow-up Study of Short-Course Chemotherapy for Pulmonary Tuberculosis
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Choi Byoung-Whui
Kim Yong-Hoon
Woo Jun-Hee
Lee Young-Hyun
Shim Young-Soo
Kim Keun-Youl
Han Yong-Chul
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Abstract
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A clinical study was done on 381 pulmonary tuberculosis patients treated with streptomycin, isoniazid, rifampicin and pyrazinamide(SHRZ). Out of 381 patients, 197(51.7%) have completed the prescribed duration or more of the treatment and 184 Patients(48.3%) have dropped out due to various reasons. Among 197 patients who have completed the chemotherapy, 82 patients have been treated beyond the 9 months treatment due to mainly drug resistance and retreatment. The most common cause of premature interruption was drop-out against advice. One hundred twelve patients have been followed up for more than 6 months after the termination of chemotherapy, and 86 were followed up for more than twelve months.
There were no relapse at all. Among 279 patients who have been on treatment for more than one month, 58 patients (20.9%) experienced adverse reactions: 22(7.9%) changed the regimen: others unchanged. The most frequent adverse reaction was hepatotoxicity. In conclusion, SHRZ for 9 month was very effective, however, change of regimen might be necessary in case of side effect or drug-resistant case.
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